Fantastic Four

John Byrne's Fantastic Four run is the second-greatest creative achievement in the character's history after Lee and Kirby's founding run — a systematic reinvention of the team that returned to their core dynamics while introducing major concepts including She-Hulk's substitution for Thing, the death and rebirth of Galactus, the introduction of Frankie Raye as Nova, and the extended Reed Richards trial before the Shi'ar Imperial Guard that is one of the most conceptually ambitious single storylines in 1980s Marvel.

The second Byrne Fantastic Four omnibus covers the conclusion of his major run, including Sue Storm's evolution from Invisible Girl to Invisible Woman, the extended Secret Wars connection, the Thing's return from self-imposed exile, and a major Doctor Doom conflict that reinforces Doom as one of the team's defining enemies.